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This refreshing cantaloupe smoothie recipe is lightly sweet and delicately fruity! All you need are 4 ingredients plus ice.

Cantaloupe smoothie in two glasses
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Got extra melon on hand? Try this refreshing Cantaloupe Smoothie! This one is lightly sweet and delicately fruity, balancing the melon with frozen pineapple and creamy Greek yogurt. If you have this sweet melon on hand, it’s a great way to use up leftovers! It’s bursting with flavor and takes just minutes to blend up. All you need are four ingredients, plus ice.

Ingredients in a cantaloupe smoothie

Melon is unique in smoothies because of the texture it produces: it becomes mostly liquid when blended. So instead of adding thickness to a smoothie texture like frozen berries or banana, melon makes it watery. It’s important to combine melon with another fruit and ice to make a thick puree! Greek yogurt is also perfect for adding creaminess and accentuating the melon flavor. Here’s what you’ll need for this cantaloupe smoothie recipe:

  • Cantaloupe: Make sure the melon is ripe before using it in smoothies. Remove the rind and chop it into bite-sized pieces before blending.
  • Frozen pineapple: Frozen fruit adds an important texture element to this melon smoothie. Pineapple has a sweet flavor with a light tropical essence that melds well with the cantaloupe without overpowering it.
  • Greek yogurt: Greek yogurt adds protein and texture to the smoothie. If desired, you can substitute vanilla yogurt or even oat milk for a vegan smoothie.
  • Orange juice: Orange juice brings a subtle sweetness and fruity flavor to the smoothie.
  • Ice: Ice adds a frosty, fluffiness to the texture.
Cantaloupe smoothie with cantaloupe chunk and two straws

Note on Greek yogurt

Greek yogurt is ideal for smoothies: it adds a creamy texture to the puree and a significant amount of protein to make it satiating. Using Greek yogurt, each serving has 10 grams protein or around 20% of your daily need! Substitute other types of yogurt if you don’t have it on hand: preferably plain yogurt without added sweeteners, but vanilla yogurt also works well.

For a vegan or dairy free cantaloupe smoothie, substitute oat milk, coconut milk or vegan yogurt for the Greek yogurt. You’ll also want to consider one of the protein adders below to make the smoothie taste filling.

Other protein adders

Want to add more protein to this cantaloupe smoothie? This is a good move if you’re planning to use it as a meal replacement, like for breakfast. Stay away from nut butter here, since it competes with the delicate melon flavor. Here are a few good options:

  • Chia seeds. Add protein and fiber with chia seeds! 2 tablespoons chia seeds adds 4 grams protein and 11 grams fiber. (See Chia Seed Smoothie.)
  • Vanilla protein powder: Use your favorite protein powder: look for a brand that has natural ingredients and experiment to find a flavor you like. The vanilla protein powder we use has a good flavor that doesn’t taste too artificial.
Cantaloupe smoothie

More fruit smoothies

Love the tropical flavor of melon in a smoothie, or prefer citrus or berry flavors? Here are a few more fruit smoothies to choose from:

This cantaloupe smoothie recipe is…

Vegetarian and gluten-free. For vegan, plant-based, and dairy-free, substitute oat milk or vegan yogurt.

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Cantaloupe smoothie

Cantaloupe Smoothie

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5 from 2 reviews

  • Author: Sonja Overhiser
  • Prep Time: 5 minutes
  • Cook Time: 0 minutes
  • Total Time: 5 minutes
  • Yield: 2 small smoothies 1x
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This refreshing cantaloupe smoothie recipe is lightly sweet and delicately fruity! All you need are 4 ingredients plus ice.


  • 3 cups cubed cantaloupe
  • 1 cup frozen pineapple
  • ½ cup Greek yogurt (or oat milk, coconut milk or vegan yogurt)
  • ½ cup ice
  • ½ cup orange juice


  1. Place the cantaloupe in a blender first and blend for a few seconds. Then add all other ingredients and blend until smooth, adding additional orange juice if necessary. Taste and if desired, add a bit of honey or pure maple syrup to sweeten. Serve immediately. Store up to 1 day refrigerated; it will separate so shake before serving.
  • Category: Drink
  • Method: Blended
  • Cuisine: Smoothie
  • Diet: Vegetarian

About the authors

Sonja & Alex

Hi, we’re Alex and Sonja Overhiser, married cookbook authors, food bloggers, and recipe developers. We founded A Couple Cooks to share fresh, seasonal recipes and the joy of cooking! Our recipes are made by two real people and work every time.

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  1. Lorraine Streeb says:

    I made the cantaloupe smoothie. I had home grown cantaloupe. I cut the recipe by 1/2 since I just wanted one serving. I used frozen pineapple, greek plain yogurt, and apple juice. Unfortunately my cantaloupe chunks were really big. Next time I’ll cut them up more. I didn’t need any ice. This was so refreshing, cooling and delicious!!! Thanks for the recipe. Next time I’ll add just a bit of honey or sugar. This time it was more like a sorbet! YUM.

  2. Sonja Overhiser says:

    Let us know if you have any questions!